Este fenómeno es conocido como efecto Jod-Basedow. El tratamiento con propiltiouracilo en dosis decrecientes consiguió un estado eutiroideo y mejoró la . Efectos de las hormomas tiroideas en el corazón. Visits . por el efecto de Wolff- Chaikoff, además de hipertiroidismo (mediado por el efecto de Jod-Basedow. de hipertiroidismo (mediado por el efecto de Jod-Basedow. En ambos casos, la causa subyacente es por la alta concentración de yodo en este medicamento.
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Iodide induced hyperthyroidism with computed tomography contrast fluids. Mico Endocrinogo de la Clica Comfamiliar Risaralda. This page was last edited on 10 Augustat Jan Wolff and Israel Lyon Chaikoff at the University of California, is a presumed reduction in thyroid hormone levels caused by ingestion of a large amount of iodine. Nutritional, Biochemical, Pathological and Therapeutic Aspects.
Goodman and Gilman’s the pharmacological basis of therapeutics 9th ed.
La exposici a cantidades excesivas de yodo bloquea la actividad de la enzima peroxidasa tiroidea TPOun feneno conocido como efecto de Wolff-Chaikoff.
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Thyroid hormones have a significant impact on heart function, mediated by genomic and non-genomic effects. Subscriber If you already have your login data, please click here. Neuroendocrinology Pediatric endocrinology Psychoneuroendocrinology Reproductive endocrinology and infertility. Dorland’s Illustrated Medical Dictionary. Cardiac afterload is increased, and chronotropic and inotropic functions are reduced. Clinically, this effect can lead to hypothyroidism. On the other hand, when thyrocites have low iodine levels and are exposed to a high iodine concentration, they increase significantly their production of thyroid hormone thus leading to hyperthyroidism, a phenomenon known as Jod-Basedow effect.
November – December Pages In larger amounts [potassium iodide] acts immediately to block further uptake of iodide by several means, particularly by saturating the iodide transport mechanisms of the thyroid, by inhibiting the intrathyroidal organification of iodide, and by simple dilution. Thyroiditis and iodide mumps following an angioplasty. In some ways the Jod-Basedow phenomenon is the opposite of the Wolff—Chaikoff effectwhich refers to the short period of thyroid-hormone suppression which happens in normal persons and in persons with thyroid disease, when comparatively large quantities of iodine or iodide are ingested.
N Engl J Med. In both instances, the underlying cause is the high concentration of iodine in this medication. Med J Aust ; 4: The risk of CHD mortality and atrial fibrillation but not other outcomes in subclinical hyperthyroidism is higher among patients with very low levels of thyrotropin.
However, unlike the Wolff-Chaikoff effectthe Jod-Basedow effect does not occur in persons with normal thyroid glands, as thyroid hormone synthesis and release in normal persons is controlled by pituitary TSH secretion which does not allow hyperthyroidism when extra iodine is ingested. Views Read Edit View history. Kid- ney Int Suppl ; Archives efectoo Internal Medicine ; 2: The Jod-Basedow effect has also been seen as a jkd effect of administration of the iodine-containing contrast agents, or amiodaronean antiarrhythmic drug.
Iodine and thyroid disease. The Jod-Basedow effect also Jod-Basedow syndrome and Jod-Basedow phenomenon is hyperthyroidism following administration of iodine or iodide,  either as a dietary supplement or as contrast medium.
Jod-Basedow phenomenon – Wikipedia
This page was last edited on 7 Augustat The Japanese-Brazilian thyroid study. The Wolff—Chaikoff effect discovered by Drs.
Thyroid hormones upregulate the expression of the sarcoplasmic reticulum calcium-activated ATPase and downregulate the expression of phospholamban.
Iodine excess and hyperthyroidism. Bull N Y Effcto Med.
Effect of iodinated contrast media on thyroid function in adults. Hyperthyroid subjects given iodide may experience a decrease in basal metabolic rate that is comparable to that seen after thyroidectomy. Eur Radiol ;14 5: Subclinical thyroid dysfunctions are independent risk factors for mortality in a 7.
Wolff-Chaikoff Effect vs. Jod-Basedow Phenomenon | Medicine Specifics
Subscribe to our Newsletter. Hospital Departamental Santa Sof de Caldas. Association between iodinated contrast media exposure and incident hyperthyroidism and hypothyroidism. Physiology of the endocrine system.